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. 2018 Mar 20;15(5):7817–7827. doi: 10.3892/ol.2018.8299

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Copyright: © Xiong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — DADS downregulates the expression of uPA and MMP-9, and upregulates TTP expression in a dose- and time-dependent manner in breast cancer cells. Western blot analysis of (A) cells treated with different concentrations of DADS (0, 100, 200 and 400 µM) for 24 h and (B) cells treated with 200 µmol/l DADS for different periods of time (0, 6, 12, 24 and 48 h). (a) MCF-7 cells. (b) MDA-MB-231 cells. *^#ΔP<0.05 vs. 0 µmol/l DADS or 0 h group; n=3. Data are presented as the mean ± standard deviation. DADS, diallyl disulfide; MMP, matrix metalloproteinase; uPA, urokinase-type plasminogen activator; TTP, tristetraprolin.