Figure 1.

Eag1 channels are up-regulated by estradiol, and in cervical cancer. (A) 17β-estradiol (E2) enhances Kcnh1 mRNA expression in the cervix of non-transgenic (FVB) and transgenic (K14E7) mice, but the highest levels were found in the cervical cancer group (K14E7 + E2, 7 months old). Four independent experiments (mean ± SD), *P<0.05, **P<0.005, ***P<0.001, and ****P<0.0001 vs. the corresponding FVB group, unless indicated. (B) Protein expression was studied by immunohistochemistry in 4-month-old (a-d) and 7-month-old (e-h) mice. The presence of the protein is revealed as brown immunostaining, n=3 mice per group. Magnification, ×20.