. 2018 Mar 21;15(5):8072–8078. doi: 10.3892/ol.2018.8310

Table III.

Multivariate analysis of the association of prognostic factors with five-year outcomes.

	Recurrence-free survival				Distant metastasis-free survival				Overall survival

		95% CI				95% CI				95% CI

Variable	HR	Lower	Upper	P-value	HR	Lower	Upper	P-value	HR	Lower	Upper	P-value
Periostin expression	3.450	1.240	9.603	0.018^a	2.305	1.111	4.781	0.025^a	2.298	1.013	5.213	0.047^a
Age	0.992	0.952	1.035	0.721	1.014	0.986	1.042	0.339	1.027	0.999	1.056	0.061
Tumor size	5.569	1.616	19.194	0.007^a	1.244	0.588	2.630	0.569	0.935	0.414	2.112	0.872
Histological grade	1.128	0.378	3.366	0.829	1.535	0.723	3.259	0.265	2.435	1.030	5.759	0.043^a
Nodal status	1.609	0.566	4.575	0.373	3.169	1.421	7.067	0.005^a	3.986	1.618	9.823	0.003^a
Phenotype	0.226	0.079	0.644	0.005^a	1.187	0.636	2.215	0.590	0.998	0.533	1.866	0.994
ER status	0.190	0.029	1.232	0.082	1.362	0.291	6.376	0.695	0.259	0.042	1.611	0.147
PR status	1.044	0.191	5.723	0.960	1.002	0.335	2.999	0.997	2.959	0.795	11.015	0.106
HER2 status	0.738	0.248	2.196	0.585	0.801	0.342	1.877	0.610	0.918	0.374	2.253	0.851
Ki-67 expression	8.800	1.623	47.731	0.012^a	1.078	0.452	2.573	0.865	0.336	0.138	0.816	0.016^a

P<0.05. HR, hazard ratio; CI, confidence interval; ER, estrogen receptor; PR, progesterone receptor; HER2, ErbB2 receptor tyrosine kinase 2.