Figure 4.

Western blot analysis for FAK and pFAK expression in osteosarcoma cells after treatment with anti-CD155 mAb or in osteosarcoma tissue. (A) Immunoblotting showed that CD155 blockade decreased FAK and pFAK protein levels ~60–70% relative to cells treated with control immunoglobulin G in K7M2 cells. Data are presented as the mean ± standard deviation from four independent experiments (n=4), *P<0.05. (B) Lung metastatic tumor tissues expressed higher levels of FAK and pFAK than primary tumor tissues. FAK, focal adhesion kinase; p, phosphorylated.