Table II.
Comparison of laboratory parameters and clinical characteristics of essential thrombocythemia patients stratified by their ASXL1 mutational status.
| Parameter/characteristic | ASXL1-mutant (n=14) | ASXL1-wt (n=58) | P-value |
|---|---|---|---|
| Age at diagnosis | 52.5; 51.1±17.5 | 57; 56.8±13.7 | 0.187 |
| Female sex | 8 (57.1) | 32 (55.1) | 1.000 |
| WBC count, ×109/l | 8.24; 9.0±3.56 | 8.83; 9.8±5.48 | 0.643 |
| Hemoglobin, g/l | 135.5; 135.4±23.0 | 132.9; 136.7±30.4 | 0.881 |
| Platelet count, ×109/l | 680; 586±276.7 | 671.5; 702±367.6 | 0.274 |
| Bleeding | 0 (0) | 4 (6.9) | 0.718 |
| Dizziness, palpitation, chest congestion | 2 (14.3) | 18 (31.0) | 0.356 |
| Numbness | 0 (0) | 7 (12.1) | 0.387 |
| Feeble | 2 (14.3) | 8 (13.8) | 1.000 |
| Splenomegaly/hepatomegaly Previous history | 2 (14.3) | 7 (12.1) | 1.000 |
| Hypertension | 1 (7.1) | 12 (20.7) | 0.426 |
| Coronary heart disease | 2 (14.3) | 5 (8.6) | 0.889 |
Values are expressed as the ‘median; mean (standard deviation)’ or as ‘n (%)’. WBC, white blood cell; ASXL1, additional sex combs like 1; wt, wild-type.