Table 1.

Effects of Monosubstitution on the Aryl Ring on Activity in the SMN-luc Reporter Gene Assay^a

Compd #	Ar	EC50 (µM)	% Activation	Compd #	Ar	EC50 (µM)	% Activation
4		1.8	242	4a		1.8 ± 0.12	182 ± 26
4b		0.86 ± 0.13	160 ± 20	4c		0.28 ± 0.03	190 ± 32
4d		0.26 ± 0.04	175 ± 13	4e		0.34 ± 0.03	180 ± 32
4f		6.2 ± 0.3	114 ± 2	4g		2.8 ± 0.61	168 ± 23
4h		7.3 ± 2.4	80 ± 15	4i		3.6 ± 1.0	147 ± 7
4j		5.4 ± 0.7	125 ± 25	4k		1.8 ± 0.9	150 ± 12
4l		1.4 ± 0.3	200 ± 10

^aData are expressed as SEM. Compounds were analyzed in duplicate on two separate occasions, and compounds with >150% induction and EC₅₀ < 1 µM were repeated (n = 3).