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Mouse Pharmacokinetic Data for 4m and 27
| compd | dose (mg/kg) |
plasma Cmax (ng/mL) |
plasma AUC0–24h (ng·h/mL) |
plasma Tmax (h) |
plasma T1/2 (h) |
brain Cmax (ng/mL) |
brain AUC0–24h (ng·h/mL) |
brain Tmax (h) |
brain T1/2 (h) |
B/P |
|---|---|---|---|---|---|---|---|---|---|---|
| 4m | 20 mpk ip | 3 | - | 6 | ||||||
| 27 | 20 mpk ip | 7660 | 34291 | 0.5 | 2.2 | 13500 | 51310 | 0.5 | 1.9 | 1.5/1 |
| 27 | 20 mpk po | 286 | 1641 | 0.5 | 3.4 | 446 | 2223 | 0.5 | 2.8 | 1.4/1 |
