Table I.
Demographic characteristics and baseline biochemical parameters of the study population.
| Parameters | CAD patients undergoing CA | Control group: No CAD patients undergoing CT | P-value |
|---|---|---|---|
| No. | 20 | 17 | |
| Age (years) | 64.8±10.4 | 71.9±14.3 (P=0.089) | |
| Sex | |||
| Male | 13 | 12 | |
| Female | 7 | 5 | |
| Weight (kg) | 81.5±10.1 | 72.4±9.39 | 0.009 |
| Height (cm) | 169±8.15 | 164±4.56 | 0.569 |
| BMI | 28.6±2.89 | 25.6±6.32 | 0.013 |
| Smoking | 13 (3 ex-smokers) | 9 | 0.569 |
| Chronic treatment | |||
| Anti-platelets | 13 | 10 | |
| Anti-coagulants | 4 | 4 | |
| β-blockers | 12 | 10 | |
| Ca channel blockers | 7 | 9 | |
| ACE inhibitors | 9 | 6 | |
| Diuretics | 8 | 8 | |
| Statins - antilipidemics | 14 | 13 | |
| Anti-diabetics | 3 | 3 | |
| Laboratory data | |||
| Hematocrit | 38.3±4.21 | 39.1±6.58 | 0.183 |
| Hemoglobin | 12.7±1.85 | 13.1±1.15 | 0.325 |
| P/L | 92.4±23.3 | 93.4±26.6 | 0.111 |
| N/L | 2.38±0.714 | 2.33±0.324 | 0.563 |
| Glucose (mg/dl) | 115±26.9 | 126±46.1 | 0.842 |
| Insulin | 16.3±11.9 | 12.4±8.41 | 0.278 |
| FIRI | 73.6±46.9 | 76.4±63.0 (20.4–180) | 0.456 |
| Creatinine (mg/dl) | 0.796±0.217 | 1.06±0.190 | 0.001 |
| Urea (mg/dl) | 38.8±13.4 | 42.8±23.2 | 0.518 |
| Uric acid (mg/dl) | 5.59±1.67 | 4.99±2.43 | 0.509 |
| Cholesterol (mg/dl) | 188±49.7 | 194±59.7 | 0.183 |
| Triglycerides (mg/dl) | 132±45.1 | 145±45.1 | 0.286 |
| HDL (mg/dl) | 46.3±14.8 | 56.3±34.8 | 0.100 |
| LDL (mg/dl) | 106±32.6 | 116±44.6 | 0.177 |
| K (mmol/l) | 4.44±0.562 | 4.65±0.666 | 0.683 |
| Na (mmol/l) | 138±2.70 | 135±6.70 | 0.983 |
| Albumin (g/dl) | 41.0±3.92 | 33.0±3.92 | 0.226 |
| Total protein (g/dl) | 65.6±5.61 | 60.4±1.11 | 0.345 |
| SGOT (IU/l) | 20.5±6.59 | 28.5±2.49 | 0555 |
| SGPT (IU/l) | 19.6±9.44 | 29.5±10.4 | 0.145 |
| γ-GT (IU/l) | 13.4±2.23 | 16.4±5.23 | 0.445 |
| LDH (IU/l) | 194±56.9 | 204±69.9 | 0.256 |
| CPK (U/l) | 121±154 (38–596) | 111±16.3 | 0.888 |
| Oxidative stress markers | |||
| GSH (µmol/g Hb) | 0.516±0.482 | 1.91±0.807 | <0.001 |
| TAC (mmol DPPH/L plasma) | 0.894±0.128 | 0.956±0.150 | 0.183 |
| TBARS (µmol/l) | 3.66±1.31 | 7.32±1.34 | <0.001 |
| Catalase (U/mg Hb) | 174±30.1 | 192±67.8 | 0.301 |
| Carbonyls (nmol/mg protein) | 1.22±0.427 | 0.793±0.141 | <0.001 |
Data presented as mean ± standard deviation (SD). Statistical comparison is made between groups 1 and 2.
a
P<0.05
b
P<0.01. ACE, angiotensin converting enzyme; BMI, body mass index, BMI=weight (kg)/(height)2 (m2); CAD, coronary artery disease; CT, computed tomography; CA, coronary angiography; ARB, angiotensin receptor blockers; N/L, neutrophils to lymphocytes ratio; P/L, platelets to lymphocytes ratio; CRP, C-reactive protein; FIRI, (glucose × insulin)/25; TAC, total anti-oxidant activity; GSH, glutathione; TBARS, thio-barbituric acid reactive species.