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Schematic model of pathogenic progression of RA with the contribution of FLS-specific genetic factors. Abbreviations: FLS, fibroblast-like synoviocytes; HLA-SE, human leucocyte antigen shared epitope; ACPA, Anti-citrullinated peptide antibody; ROS, reactive oxygen species; RNS, reactive nitrogen species; SNP, single nucleotide polymorphism; mtDNA, mitochondrial DNA.
