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. Author manuscript; available in PMC: 2019 Apr 21.
Published in final edited form as: Lancet. 2018 Feb 7;391(10130):1599–1607. doi: 10.1016/S0140-6736(18)30204-6

Figure 1. Characteristics of PCR-confirmed active yaws by epidemiological history, molecular type, and macrolide resistance mutation.

Figure 1

PCR-confirmed active yaws refers to samples with positive results in either tpN47 (tp0574) or tp0548, and in which the pertenue subspecies was confirmed by TprL PCR amplicon size.

*A random sample of 90 (out of 690) clinically suspected yaws cases at baseline and 84 (out of 121) at 6 months were tested by PCR; we provide data on the characteristics of lesions that were actually PCR-positive among the subset of PCR-tested lesions (31 at baseline and 41 at 6-months). In 12-month to 42-month surveys, we tested all clinically suspected lesions by PCR; therefore we provide data on the characteristics of all lesions detected for these time-points.

†Not all T. p. pertenue positive samples could be fully typed for all three typing targets.

§ P<0.0001 for the estimate of the mean evolutionary diversity of T. p. pertenue isolates at 24-month survey compared to baseline.

¶ Estimate of the mean evolutionary diversity of T. p. pertenue isolates at each round.

‡Not all T. p. pertenue positive samples could be amplified for 23S rRNA by PCR.