Extended Data Table 1.
Summary of Fos expression in saline- or STZ-treated C57BL/6 mice.
| Saline | STZ | ||
|---|---|---|---|
| Cortex | Frontal association cortex | + | − |
| Dorsal peduncular cortex | + | − | |
| Infralimbic cortex | + | +++ | |
| Prelimbic cortex | + | ++++ | |
| Cingulate cortex | ++ | +++ | |
| Orbital cortex, lateral | ++ | +++ | |
| Orbital cortex, ventral/medial | ++ | ++++ | |
| Orbital cortex, dorsal | + | +++ | |
| Motor cortex, primary | ++ | ++ | |
| Motor cortex, secondary | ++ | ++ | |
| Agranular insular cortex | ++ | + | |
| Dysgranular/granular insular cortex | + | + | |
| Somatosensory cortex | ++ | ++ | |
| Auditory cortex | + | ++ | |
| Visual cortex | ++ | ++++ | |
| Entorhinal cortex | + | ++ | |
| Retrosplenial cortex | ++ | + | |
| Perirhinal cortex | + | + | |
| Ectorhinal cortex | + | + | |
| Parietal cortex | ++ | +++ | |
| Olfactory bulb | +++ | +++++ | |
| Olfactory areas | Anterior olfactory nucleus | ++ | ++++ |
| Piriform cortex | +++ | +++++ | |
| Tenia tecta | − | + | |
| Hippocampus/Septum | Hippocampus (CA1, CA2, CA3) | + | ++++ |
| Dorsal Subiculum | − | − | |
| Hippocampus (dentate gyrus) | + | + | |
| Septum | − | − | |
| Diagonal band of Broca | ++ | ++ | |
| Claustrum/endopiriform | Claustrum | ++ | − |
| Endopiriform nucleus | + | − | |
| Olfactory tubercle | ++ | − | |
| Striatum | N.Accumbens, Shell & Core | − | − |
| Dorsal striatum | − | − | |
| Pallidum | Ventral pallidum Globus pallidus | + | − |
| Entopeduncular nucleus | − | − | |
| IPAC | + | + | |
| BNST | + | − | |
| Sublenticular extended amygdala | − | − | |
| Amygdala | Central nucleus | − | +++ |
| Anterior amygdaloid area | − | − | |
| Medial nucleus | − | − | |
| Cortical amygdaloid transition zone | − | − | |
| Basolateral nucleus | ++ | +++ | |
| Basomedial nucleus | + | + | |
| Hypothalamus | Median preoptic area | + | +++++ |
| Medial preoptic area | + | ++++ | |
| Lateral preoptic area | + | +++ | |
| Suprachiasmatic nucleus | ++ | +++++ | |
| Arcuate nucleus | + | +++++ | |
| Magnocellular preoptic area | − | +++ | |
| Anterior hypothalamic area | + | +++ | |
| Paraventricular hypothalamic nucleus | + | +++++ | |
| Ventromedial hypothalamic nucleus | ++ | + | |
| Lateral hypothalamic area | + | +++ | |
| Posterior hypothalamic area | ++ | +++ | |
| Dorsal hypothalamic area | + | ++++ | |
| Tuber cinereum area | − | +++ | |
| Perifornical nucleus | − | ++ | |
| Mammillary nucleus | − | + | |
| Premammillary nucleus | + | ++ | |
| Supramammillary nucleus | + | +++ | |
| Subthalamic nucleus | + | +++ | |
| Zona incerta | − | − | |
| Supraoptic nucleus | + | +++++ | |
| Field of Forel, Prerubral field | − | − | |
| Retrochiasmatic nucleus | + | + | |
| Thalamus/Epithalamus | Lateral habenula | − | ++ |
| Medial habenula | − | − | |
| Parafascicular thalamic nucleus | − | + | |
| Paraventricular thalamic nucleus | +++ | ++++ | |
| Lateral geniculate nucleus | + | ++ | |
| Medial genicuulate nucleus | + | ++ | |
| Mediodorsal thalamic nucleus | − | − | |
| Central medial thalamic nucleus | − | + | |
| Ventromedial thalamic nucleus | − | ++ | |
| Dorsolateral thalamic nucleus | − | − | |
| Olivary pretectal nucleus | − | ++ | |
| Midbrain | Nucleus of posterior commissure | − | + |
| Nucleus of the optic tract | − | + | |
| Anterior pretectal nucleus | − | − | |
| Interpeduncular nucleus | − | + | |
| Substantia nigra pars reticulata | − | − | |
| Substantia nigra pars compacta | − | − | |
| Ventral tegmental area | − | + | |
| Retrorubral field | − | − | |
| Reticular formation | + | + | |
| Periaqueductal gray | + | ++ | |
| Superior coliculus | + | + | |
| Inferior coliculus | ++ | ++ | |
| Red nucleus | − | − | |
| Anterotegmental nucleus | − | − | |
| Median raphe nucleus | − | − | |
| Dorsal raphe nucleus | − | − | |
| Pontine reticular nucleus | − | − | |
| Pedunculopontine tegmental nucleus | − | − | |
| Laterodorsal tegmental nucleus | − | − | |
| Subpeduncular tegmental nucleus | − | − | |
| Retrorubral nucleus | − | − | |
| Cuneiform nucleus | − | − | |
| Parageminal nucleus | − | − | |
| Dorsal tegmental nucleus | − | − | |
| Pontine raphe nucleus | − | − | |
| Locus coeruleus | + | ++++ | |
| Hindbrain | Superior olive | − | − |
| Parabrachial nucleus | + | ++ | |
| Raphe magnus nucleus | − | − | |
| Raphe pallidus nucleus | − | ++ | |
| Solitary nucleus | − | ++ | |
| Paragigantocellular reticular nucleus | − | ++ |