Table 3. Cardiovascular diseases with clear evidence that extracellular CypA plays a role in pathogenesis.

The only human data are for coronary artery disease, peripheral arterial occulusion and pulmonary arterial hypertension where plasma CypA correlated with disease progression and/or severity; and hypertension and hypercholesterolemia where platelet-bound CypA correlated with. Other studies are in mouse. The right column stands for disease in which total CypA is studied, thus we can not tell the effects of eCypA from iCypA.

Cardiovascular Diseases	eCypA	Total CypA	References
Carotid intima-media thickness		√	31, 44, 45
Coronary artery disease	√		47, 48, 49
Hypertension	√		50
Hypercholesterolemia	√		50
Atherosclerotic aortic aneurysm		√	27
Atherosclerosis	√		51, 52
Peripheral arterial occlusion	√		53
Pulmonary arterial hypertension	√		25, 37
Cardiac hypertrophy		√	59