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. 2018 Mar 2;15(5):6094–6106. doi: 10.3892/ol.2018.8157

Table III.

Principal tumor suppressor microRNAs downregulated in MM.

MicroRNAs Cell processes Validated target genes Refs.
miR-125b Cell apoptosis, cell proliferation IRF4 (56)
Let-7b Cell apoptosis, cell proliferation IGF-1R (57)
miR-29 family Cell apoptosis, cell proliferation, cell migration DNMT3A, DNMT3B, PSME4, Sp1, CDK6, MCL-1 (5862)
miR-34a Cell apoptosis, cell proliferation NOTCH1, BCL2, CDK6 (6365)
miR-202 Cell apoptosis, cell proliferation BAFF (33,66)
miR-15a/16 Cell apoptosis, cell proliferation, cell migration, cell cycle, angiogenesis FGFR1, PIK3α, PI3KC2A, MDM4, VEGF (38,67,68)
miR-214 Cell apoptosis, cell proliferation, cell cycle PSMD10, ASF1B (27)
miR-192, 194, 215 Cell apoptosis, cell proliferation, cell cycle MDM2, IL-17R (18)
miR-33b Cell apoptosis, cell proliferation, cell migration PIM-1 (69)
miR-126 Cell proliferation C-MYC (70)
miR-130b Cell apoptosis, cell proliferation GR-α (71)

miR, microRNA; MM, multiple myeloma; IRF4, interferon regulatory factor 4; IGF-1R, insulin-like growth factor 1 receptor; DNMT, DNA methyltransferase; PSME4, Proteasome activator complex subunit 4; FGFR1, Fibroblast growth factor receptor 1; VEGF, Vascular endothelial growth factor; PSMD10, 26S proteasome non-ATPase regulatory subunit 10; ASF1B, anti-silencing function 1B histone chaperone; Sp1, stimulatory protein 1; CDK6, cyclin dependent kinase 6; MCL-1, myeloid cell leukemia-1; NOTCH1, Notch homolog 1; BCL2, B-cell lymphoma 2; BAFF, B cell activating factor belonging to the TNF family; C-MYC, v-myc avian myelocytomatosis viral oncogene homolog; PIK3α, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α; PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2α; MDM4, MDM4, p53 regulator; MDM2, MDM2 proto-oncogene; IL, interleukin; PIM-1, pim-1 proto-oncogene, serine/threonine kinase; GR-α, glucocorticoid receptor α; Refs., references.