Table III.
MicroRNAs | Cell processes | Validated target genes | Refs. |
---|---|---|---|
miR-125b | Cell apoptosis, cell proliferation | IRF4 | (56) |
Let-7b | Cell apoptosis, cell proliferation | IGF-1R | (57) |
miR-29 family | Cell apoptosis, cell proliferation, cell migration | DNMT3A, DNMT3B, PSME4, Sp1, CDK6, MCL-1 | (58–62) |
miR-34a | Cell apoptosis, cell proliferation | NOTCH1, BCL2, CDK6 | (63–65) |
miR-202 | Cell apoptosis, cell proliferation | BAFF | (33,66) |
miR-15a/16 | Cell apoptosis, cell proliferation, cell migration, cell cycle, angiogenesis | FGFR1, PIK3α, PI3KC2A, MDM4, VEGF | (38,67,68) |
miR-214 | Cell apoptosis, cell proliferation, cell cycle | PSMD10, ASF1B | (27) |
miR-192, 194, 215 | Cell apoptosis, cell proliferation, cell cycle | MDM2, IL-17R | (18) |
miR-33b | Cell apoptosis, cell proliferation, cell migration | PIM-1 | (69) |
miR-126 | Cell proliferation | C-MYC | (70) |
miR-130b | Cell apoptosis, cell proliferation | GR-α | (71) |
miR, microRNA; MM, multiple myeloma; IRF4, interferon regulatory factor 4; IGF-1R, insulin-like growth factor 1 receptor; DNMT, DNA methyltransferase; PSME4, Proteasome activator complex subunit 4; FGFR1, Fibroblast growth factor receptor 1; VEGF, Vascular endothelial growth factor; PSMD10, 26S proteasome non-ATPase regulatory subunit 10; ASF1B, anti-silencing function 1B histone chaperone; Sp1, stimulatory protein 1; CDK6, cyclin dependent kinase 6; MCL-1, myeloid cell leukemia-1; NOTCH1, Notch homolog 1; BCL2, B-cell lymphoma 2; BAFF, B cell activating factor belonging to the TNF family; C-MYC, v-myc avian myelocytomatosis viral oncogene homolog; PIK3α, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α; PIK3C2A, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2α; MDM4, MDM4, p53 regulator; MDM2, MDM2 proto-oncogene; IL, interleukin; PIM-1, pim-1 proto-oncogene, serine/threonine kinase; GR-α, glucocorticoid receptor α; Refs., references.