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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Orthop Res. 2017 Aug 29;36(3):864–875. doi: 10.1002/jor.23671

Figure 4.

Figure 4

Longitudinal activity patterns in wild-type and Ccr7−/− mice subjected to DMM surgery. Spontaneous activity was measured pre-operatively and every 4 weeks up to 16 weeks post-operatively using LABORAS platforms (details in materials and methods). Median (IQR) time spent climbing (A), in locomotion (B), and distance traveled (C) in 14 h is presented. In wild-type mice, time spent climbing (A) decreased slightly although non-significantly after DMM surgery compared to baseline up to 8 weeks post-operatively. CCR7−/− mice increased climbing activity compared to baseline up to 8 weeks with decreases thereafter. Similar longitudinal patterns were seen with locomotion (B) and distance travelled (C). (*p < 0.01 compared to pre-op levels in same strain, #p <0.05 for trend difference between strains using linear mixed effects models).