Table 2.2.

SNPs from the TOMM40, APOC1, APOE and PVRL2 (NECTIN2) genes that showed most significant associations in GWAS of AD in CHS, FHS and HRS using Cox regression.

Dataset	SNP	p-Value	HR	Chr	Ref	Alt	MAF	Gene	Location
CHS	rs2075650	1.99E–15	2.3	19	A	G	0.12	TOMM40	Intron (LD with rs429358, rs769449 in APOE)
	rs12721046	2.39E–14	2.2	19	G	A	0.08	APOC1	Intron (LD with rs769449 and rs429358 in APOE)
	rs405509	1.16E–05	1.4	19	T	G	0.47	APOE	Upstream, promoter
	rs6859	2.87E–05	1.4	19	A	G	0.37	PVRL2	3′-UTR
	rs8106922	8.34E–05	0.7	19	A	G	0.30	TOMM40	Intron
FHS	rs12721046	2.93E–09	2.0	19	G	A	0.08	APOC1	Intron (LD with rs769449 and rs429358 in APOE)
	rs2075650	1.46E–05	1.7	19	A	G	0.12	TOMM40	Intron (LD with rs429358, rs769449 in APOE)
HRS	rs115881343	2.03E–09	0.5	19	C	G,T	0.03	TOMM40	Intron
	rs76366838	1.71E–08	0.4	19	G	A	0.03	TOMM40	Intron
	rs769449	3.12E–08	1.7	19	G	A	0.06	APOE	Intron (LD with rs12721046 in APOC1, rs2075650 in TOMM40, rs429358 in APOE)
	rs157582	1.68E–07	0.7	19	C	T	0.29	TOMM40	Intron
	rs283815	3.07E–07	0.7	19	A	G	0.30	PVRL2	Intron (LD with rs429358 in APOE)
	rs2075650	5.17E–07	1.5	19	A	G	0.12	TOMM40	Intron (LD with rs429358, rs769449 in APOE)
	rs71352238	3.19E–06	1.5	19	T	C	0.09	TOMM40	Intron

The columns notations: dataset name, SNP name, p-value in Cox regression, Hazard Ratio (HR) for Cox regression, chromosome (Chr), reference allele (Ref), alternative allele (Alt), minor allele frequency (MAF), gene’s name and location with LD information.