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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Physiol Behav. 2017 Oct 26;203:70–80. doi: 10.1016/j.physbeh.2017.10.025

Fig. 1.

Fig. 1

Timeline of experimental procedures in days. After acclimation, rats underwent gonadectomy (OVX, CAST), sham surgery (SHAM), or no surgery (INTACT). Following recovery, rats received hormone (estradiol [E2] in females, testosterone [T] in males) or vehicle injections for 5–7 days prior and throughout ethanol self-administration. During extinction (EXT) and reinstatement (REIN), chronic hormone treatments ceased. Rats were acutely treated with either E2, T, PHTPP, fulvestrant (FULV), or clomiphene (CLOM) prior to cue+yohimbine- induced reinstatement of ethanol seeking.