Fig. 2.

Ethanol self-administration in gonadally-intact female rats. Females that were later tested for the effects of fulvestrant (Fulv), clomiphene (Clom), or PHTPP showed typical acquisition of ethanol self-administration, increasing the amount of reinforcers earned (A) and ethanol intake (B) across the three weeks of training. Across all gonadally- intact rats (INTACT and SHAM), no significant differences as a function of phase of the estrous cycle were evident on the last day of ethanol self-administration (C). Representative pictographs of vaginal cytology are shown in (D).