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. 2018 Mar 8;15(5):4522–4530. doi: 10.3892/etm.2018.5935

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Figure 5. — Cell apoptosis and mice survival rate in rNDV-p53 treated glioma. (A) TUNEL-positive glioma cells following treatment with rNDV-p53, rNDV-EGFP or PBS (magnification, ×20). (B) p53, p21 and caspase3 and (C) Bcl-2, Bax and Bim expression in tumors from experimental mice following treatment with rNDV-p53, rNDV-EGFP or PBS (magnification, ×20). (D) Survival rates of rNDV-p53, rNDV-EGFP or PBS treated U251-bearing mice over a 180-day observation. **P<0.01 vs. control. rNDV, recombinant Newcastle disease virus; EGFP, enhanced green fluorescent protein; Bcl-2, B cell lymphoma-2; Bax, Bcl-2 associated X; Bim, Bcl-2 like 11.