Figure 4.

miR-149 increased the sensitivity of SKOV-3 cells to cisplatin and inhibited ovarian cancer cell proliferation in an XIAP-dependent manner. (A) The sensitivity of SKOV-3 cells co-transfected with miR-149 mimics and XIAP expression vector to cisplatin treatment was measured by an MTT assay. (B) Colony formation and (C) flow cytometry assays were performed to detect the proliferation ability and apoptosis rate, respectively, of SKOV-3 cells co-transfected with miR-149 mimics and XIAP expression vector. Error bars represent the mean ± standard deviation of at least three independent experiments. *P<0.05 and **P<0.01, vs. corresponding control group. XIAP, X-linked inhibitor of apoptosis; miR, microRNA; NC, negative control.