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. 2018 Mar 6;15(5):6947–6956. doi: 10.3892/ol.2018.8180

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Reduced expression of miR-192-5p and elevated expression of USP1 in osteosarcoma tissues and cell lines. (A) miR-192-5p expression was statistically lower in osteosarcoma tissues than in adjacent non-tumor tissues. (B) USP1 expression was significantly higher in osteosarcoma tissues when compared with adjacent non-tumor tissues. (C) There was a negative correlation between miR-192-5p and USP1 in osteosarcoma tissues. (D) The expression of miR-192-5p was downregulated in the osteosarcoma cell lines (143B and U2OS) when compared with the normal human osteoblast cell line (hFOB). (E) The expression of USP1 was increased in the 143B and U2OS cell lines compared with that of osteosarcoma. (F) Kaplan-Meier survival analysis suggested that osteosarcoma patients with low expression of miR-192-5p presented a shorter overall survival. The results are presented as the mean ± standard deviation of 3 independent assays. ***P<0.001, as indicated. miR, microRNA; USP1, ubiquitin-specific protease 1.