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. 2018 Mar 6;15(5):6947–6956. doi: 10.3892/ol.2018.8180

Figure 2.

Figure 2.

Upregulation of miR-192-5p inhibited osteosarcoma cell proliferation and induced cell cycle at the G0/G1 stage and cell apoptosis. (A) Reverse transcription-quantitative polymerase chain reaction was performed to measure the expression of miR-192-5p in 143B and U2OS cells following transfection with miR-192-5p-mimics. Overexpression of miR-192-5p significantly restrained the proliferation of (B) 143B and (C) U2OS cells. (D) The cell cycle assay demonstrated that miR-192-5p mimics could prevent the progression of the cell cycle from the G1 to S phase in 143B and U2OS cells. (E) Elevated expression of miR-192-5p markedly induced 143B and U2OS cells apoptosis. Data are presented as the mean ± standard deviation of 3 independent assays. *P<0.05, **P<0.01 and ***P<0.001 vs. miR-NC. miR, microRNA; NC, negative control; FITC, fluorescein isothiocyanate; PI, propidium iodide.