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. 2018 Mar 6;15(5):6947–6956. doi: 10.3892/ol.2018.8180

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Overexpression of miR-192-5p suppressed osteosarcoma cell migration and invasion, and enhanced the sensitivity of osteosarcoma cells to cisplatin. (A) Wound-healing assay revealed that the migratory ability of 143B and U2OS cells was suppressed by miR-192-5p mimics (magnification, ×100). (B) Transwell assay was conducted to evaluate the invasion of 143B and U2OS cells following treatment with mR-192-5p, which suggested that the capacity of invasion was significantly decreased in the treatment group (magnification, ×100). (C) The response of 143B cells to cisplatin enhanced following transfection with the miR-192 mimic compared to the negative control. (D) The response of U2OS cells to cisplatin enhanced following transfection with the miR-192 mimic compared with the negative control. Data are presented as the mean ± standard deviation of 3 independent assays. *P<0.05 and **P<0.01 vs. miR-NC. miR, microRNA; NC, negative control.