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. 2018 Mar 7;15(5):7060–7068. doi: 10.3892/ol.2018.8204

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — TPM1 overexpression increases renal cell carcinoma apoptosis as detected by DAPI staining. (A) Representative fluorescence microscopy images of DAPI-stained cells at 36 h post-transfection (magnification, ×100 and ×200). (B) Morphological changes of nuclear chromatin at 36 h post-TPM1 overexpression in 786-O cells (magnification, ×200). The red triangle indicates stage I apoptosis characterized by a rippled or creased nucleus. The red star indicates stage IIa apoptosis characterized by a highly condensed or marginalized nucleus. The red arrow indicates stage IIb apoptosis characterized by fragments of splitting nucleus. Apoptotic cell proportions per HPF (magnification, ×200) of the different transfection groups in (C) 786-O and (D) ACHN cells. The values are presented as mean ± standard deviation from five randomly selected HPFs. *P<0.05, with comparisons indicated by brackets. TPM1, tropomyosin-1; OE, TPM1 overexpression; OE-NC, negative control for overexpression vector; KD, TPM1 knockdown; KD-NC, negative control for knockdown vector; HPF, high power field.