Table IV.

Cox regression analysis of overall survival for patients with hepatocellular carcinoma (n=78).

	Univariate analysis			Multivariate analysis
Variable	HR	(95% CI)	P-value	HR	(95% CI)	P-value
Age, years (≥57 vs. <57)	1.018	0.990–1.046	0.216
Sex (female vs. male)	0.770	0.327–1.812	0.549
Tumor size, cm (≥5 vs. <5 cm)	2.615	1.475–4.634	0.001b	1.560	0.907–1.824	0.347
Tumor number (≥2 vs. 1)	2.257	1.047–4.865	0.038a
Hepatitis B virus (positive vs. negative)	0.471	0.240–0.926	0.029a
Cirrhosis (yes vs. no)	0.813	0.365–1.811	0.612
AFP, U/l (≥400 vs. <400)	1.581	0.822–3.040	0.170
Tumor differentiation (poorly vs. moderately vs. well)	1.407	0.975–2.030	0.068
TNM stage (III+IV vs. I+II)	4.565	2.536–8.220	<0.001c	2.016	0.806–5.041	0.134
Portal vascular invasion (yes vs. no)	5.672	3.049–10.549	<0.001c	3.172	1.126–8.931	0.029a
Distant metastasis (yes vs. no)	4.030	1.893–8.579	<0.001c	1.505	0.589–3.846	0.394
SOX2 (positive vs. negative)	4.732	2.499–8.959	<0.001c	2.812	1.896–3.780	0.013a
miR-638 expression (high vs. low)	0.269	0.269–0.149	<0.001c	0.338	0.152–0.751	0.008b

^aP<0.05

^bP<0.01

^cP<0.001. HR, hazard ratio; CI, confidence interval; AFP, α-fetoprotein; TNM, Tumor-Node-Metastasis; miR, microRNA; SOX2, sex-determining region Y-box 2.