Table 3.

The change of glycans in diseases by UPLC

Glycans	CRC	UC	CD	SLE	RA	CKD	PD	HT	T2D	O	DL*	IS
GP1	↑	–	–	↑	↑	–	–	–	–	–	–	↑
GP2	↑	–	–	↑	↑	↑	–	–	–	–	↑	–
GP3	↑	–	–	–	–	–	–	–	–	–	–	–
GP4	↑	↑	↑	↑	–	–	–	↑	–	–	↑	–
GP5	↑	–	–	↑	–	–	↓	–	–	–	↑	↓
GP6	↑	↑	↑	↑	–	↑	–	↑	↑	–	↑	–
GP7	–	–	–	↑	–	–	–	–	–	–	–	–
GP8	↓	–	–	↓	–	–	↑	–	↓	–	–	↑
GP9	↓	↓	↓	↓	–	–	–	–	↓	–	–	–
GP10	↓	–	–	↑	–	–	–	–	↑	–	–	–
GP11	↓	–	–	–	–	–	–	–	↑	–	↑	–
GP12	↓	–	–	↑	–	–	–	↓	–	–	–	–
GP13	↓	–	–	–	–	–	–	↓	–	–	–	↓
GP14	↓	↓	↓	↓	–	↓	↑	↓	–	↓	↓	↓
GP15	↓	–	–	–	–	–	–	↓	–	–	–	↓
GP16	↑	–	–	↓	–	–	–	–	–	–	–	–
GP17	–	–	–	↑	–	–	↓	–	–	–	–	↓
GP18	↓	↓	↓	↓	–	↓	–	↓	–	↓	↓	↓
GP19	↓	–	↓	↑	–	–	–	–	–	–	–	–
GP20	–	–	–	–	–	–	↓	–	–	–	↑	–
GP21	–	–	–	–	–	–	↓	–	–	–	↑	↓
GP22	↓	–	–	↑	↓	–	↓	–	–	–	–	–
GP23	–	–	–	↓	–	–	–	–	–	–	–	↓
GP24	–	–	–	↑	↑	–	–	–	–	–	–	–
Galactosylation	↓	↓	↓	↓	↓	↓	↓	↓	↓	↓	↓	↓
Sialylation	↓	–	↓	↓	–	↓	↓	↓	↓	–	↓	↓
Fucosylation	↑	–	–	↓	↑	–	–	↓	↓	–	–	–
Bisecting GlcNAc	↓	–	↑	↑	–	↑	–	↑	↑	–	↑	↑

↑ high level of glycans can increase the risk of disease. ↓ low level of glycans can increase the risk of disease. CRC colorectal cancer, UC ulcerative colitis, CD Crohn’s disease, SLE systemic lupus erythematosus, RA rheumatoid arthritis, CKD chronic kidney disease, PD Parkinson’s disease, HT hypertension, T2D type 2 diabetes, O obesity, DL dyslipidemia, IS ischemic stroke

*Unpublished paper