Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 1;29(9):1048–1059. doi: 10.1091/mbc.E18-02-0142

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Fu et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.

PMC Copyright notice

FIGURE 6: — Schematic model to summarize the structural features and potential functions of the T/TH complex. (A) In wild-type cilia, the tether head (TH, dark red) binds to the I1 dynein motor domains I1α and I1β (green), and the tether (T, red) connects the tether head to the A-tubule through the anchoring ridge structure. Structurally the T/TH complex links several major axonemal complexes; blue arrows indicate potential (direct) signaling pathways between the T/TH complex and these axonemal structures that are involved in regulating ciliary motility. The dotted red line indicates a transient connection between the T/TH and the I1 intermediate chain light chain complex (ICLC, purple) that is only visible in specific regions of actively beating cilia (Lin and Nicastro, 2018). (B) Failure to assemble the T/TH complex in mutants may cause interruption (blocked blue lines) of signal transduction through the T/TH complex from/to the following complexes: radial spoke 3 (RS3, orange), inner dynein arm d (IDA d, rose), the I1α and I1β dynein motor domains, and the I 1 ICLC, as well as indirectly the other dynein arms (ODA), IDA a and the nexin dynein regulatory complex (N-DRC). The T/TH complex seems also involved in proper function of the kinase/phosphatase, indicated by the hyperphosphorylation (P) of IC138 and reduction of CK1. Together, loss of the T/TH complex resulted in impaired ciliary motility.