Table 1.

Clinical and histological characteristics of dogs with iUC and healthy control dogs

Case No.	Sex	Age (months)	Breed	TNM stage at diagnosis	Papillary histology	Grade (nuclear atypia)	Type (degree) of inflammation	BRAF mutation
iUC1	F	146	Wire Fox Terrier	T2N0M0	No	Grade 2	Lyn, Neu (mild)	–
iUC2	FS	122	Papillon	T2N0M0	Yes	Grade 2	Lym (moderate)	+
iUC3	F	85	Miniature Dachshund	T3N0M0	Yes	Grade 2	Lym (moderate)	+
iUC4	F	147	Papillon	T2N0M0	Yes	Grade 3	Lym (mild)	–
iUC5	FS	131	Miniature Dachshund	T3N0M0	Yes	Grade 3	Lym, Eo (moderate)	+
iUC6	F	122	Border Collie	T2N0M0	No	Grade 2	Lym (mild)	–
iUC7	FS	149	Miniature Dachshund	T2N1M0	No	Grade 3	Lyn, Neu (mild)	+
iUC8	F	105	French Bulldog	T2N0M0	Yes	Grade 3	Lym (moderate)	+
iUC9	M	161	Pembroke Welsh Corgi	T3N1M0	Yes	Grade 2	Lym (mild)	–
iUC10	FS	158	Toy Poodle	T2N0M0	Yes	Grade 2	Lym (severe)	+
iUC11	FS	145	Mongrel	T2N0M0	Yes	Grade 1	Lym (mild)	–
HC1	F	130	Beagle	–	–	–	–	–
HC2	F	112	Beagle	–	–	–	–	–
HC3	M	97	Beagle	–	–	–	–	–
HC4	M	122	Beagle	–	–	–	–	–
HC5	M	108	Beagle	–	–	–	–	–

iUC invasive urothelial carcinoma, HC healthy control, F female, FS female spayed, M male, Lym lymphocyte, Neu neutrophil, Eo eosinophil