Table 1.
Characteristics of patient and healthy individual collective
| Polytrauma patients (n = 22) | Monotrauma patients (n = 10) | Probands (n = 10) | |
|---|---|---|---|
| Age, median (IQR) (years) | 60 (31.5) | 57.5 (32) | 45.5 (25.5) |
| Male sex, n (%) | 17 (77.3) | 4 (40) | 6 (60) |
| Blunt trauma, n (%) | 21 (95.5) | 10 (100) | – |
| ISS, median (IQR) | 26.5 (14.5) | 4 *** | 0 *** |
| AISAbdomen ≥ 3, n (%) | 4 (18.2) | 0 | 0 |
| AISThorax ≥ 3, n (%) | 16 (72.7) | 0 | 0 |
| AISHead/neck ≥ 3, n (%) | 14 (63.6) | 0 | 0 |
| AISExtremity ≥ 3, n (%) | 9 (40.9) | 2 (20) | 0 |
| Vital signs at admission | |||
| Heart rate, median (IQR) (bpm) | 100 (44.5) | – | – |
| Systolic blood pressure, median (IQR) (mmHg) | 122 (38.8) | – | – |
| Patient with shock index > 1.0, n (%) | 8 (36.4) | ||
| Blood parameters at admission | |||
| Haemoglobin, median (IQR) (g/dl) | 12 (2.2) | 14 (1) | – |
| Platelet count, median (IQR) (/nl) | 197 (49) | 249 (97) | – |
| INR, median (IQR) | 1.12 (0.1) | 1.03 (0.1) | – |
| INR > 1.2, n (%) | 4 (18) | – | |
| aPTT, median (IQR) (s) | 30 (9.1) | 24.5 (3.2) | |
| Fibrinogen, median (IQR) (g/l) | 1.8 (0.6) | – | – |
| Base excess, median (mmol/l) | −1.7 | – | – |
| ROTEM measures (study day 1) | |||
| EXTEM CT, median (IQR) (s) | 68 (19) | 65.5 (5.5) | – |
| EXTEM CFT, median (IQR) (s) | 90 (35) | 75 (14) | – |
| EXTEM MCF, median (IQR) (mm) | 61 (7) | 65.5 (3)* | – |
| FIBTEM CT, median (IQR) (s) | 60 (15) | 60.5 (5.8) | – |
| FIBTEM A10, median (IQR) (s) | 11.5 (4) | 14.5 (4.3)* | – |
| FIBTEM MCF, median (IQR) (mm) | 12 (5) | 17.5 (7.3) | – |
| Transfusion requirement (first 24 h)a | |||
| RBC, median (IQR) (unit) | 7 (14.5)* | 0 | – |
| FFP, median (IQR) (unit) | 5 (9.3)* | 0 | – |
| Platelet, median (IQR) (unit) | 0.5 (1.8) | 0 | – |
| Mortality (28 days), n (%) | 4 (18.2)** | 0 | – |
aOnly patients considered who received any type of blood products (10 patients received RBC, thereof 6 patients receiving FFP and 5 receiving platelets, respectively). Statistical significances were marked with asterisks (*p < 0.05, **p < 0.01, ***p < 0.001)