Table 3.
Adjusted odds ratios (95% confidence intervals) for the association of midlife and late-life number of vascular risk factors with elevated SUVR (global cortex SUVR>1.2) overall and stratified by APOE ε4 genotype, N=322.
| Overall (N=322) | 0 APOE ε4 Alleles (n=220) | 1 or 2 APOE ε4 Alleles (n=100) | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| No. with SUVR>1.2/Total No. (%) | Adjusted OR (95% CI) | No. with SUVR>1.2/Total No. (%) | Adjusted OR (95% CI) | No. with SUVR>1.2/Total No. (%) | Adjusted OR (95% CI) | |
| Midlife (Visit 1, 1987-1989) | ||||||
| 0 Vascular Risk Factors | 20/65 (30.8) | 1 (Reference) | 14/47 (29.8) | 1 (Reference) | 6/18 (33.3) | 1 (Reference) |
| 1 Vascular Risk Factor | 62/123 (50.4) | 1.88 (0.95, 3.73) | 37/85 (43.5) | 1.36 (0.61, 3.05) | 25/38 (65.8) | 3.10 (0.84, 11.50) |
| ≥2 Vascular Risk Factors | 82/134 (61.2) | 2.88 (1.46, 5.69) | 45/90 (50.0) | 1.86 (0.83, 4.14) | 37/44 (84.1) | 9.15 (2.27, 36.89) |
| Late-life (Visit 5, 2011-2013) | ||||||
| 0 Vascular Risk Factors | 13/35 (37.1) | 1 (Reference) | 6/23 (26.1) | 1 (Reference) | 7/12 (58.3) | 1 (Reference) |
| 1 Vascular Risk Factor | 37/82 (45.1) | 1.02 (0.43, 2.43) | 16/50 (32.0) | 1.38 (0.43, 4.39) | 21/32 (65.6) | 0.56 (0.12, 2.67) |
| ≥2 Vascular Risk Factors | 114/205 (55.6) | 1.66 (0.75, 3.69) | 74/149 (49.7) | 2.21 (0.78, 6.26) | 40/56 (71.4) | 1.03 (0.25, 4.29) |
Models adjusted for age (at visit 5, 2011-2013), sex, race, education level, APOE ε4 genotype.
Vascular risk factors included: body mass index ≥30 kg/m2, current smoking, hypertension, diabetes, and total cholesterol ≥200 mg/dl.