Table 2.

Area under the receiver-operating characteristic curve at each time point for urinary biomarkers with and without normalization to urinary creatinine for predicting advanced acute kidney injury

Urinary Biomarkers	Time after enrollment	AUC	95% CI	Urinary biomarkers	Time after enrollment	AUC	95% CI
uHJV	Hour 3	0.793	0.709 to 0.862	Normalized uHJV	Hour 3	0.833	0.753 to 0.895
	Hour 6	0.802	0.720 to 0.869		Hour 6	0.808	0.726 to 0.874
	Hour 12	0.813	0.683 to 0.907		Hour 12	0.841	0.715 to 0.927
	Hour 24	0.687	0.542 to 0.809		Hour 24	0.719	0.575 to 0.835
uKIM-1	Hour 3	0.670	0.549 to 0.776	Normalized uKIM-1	Hour 3	0.819	0.710 to 0.900
	Hour 6	0.664	0.543 to 0.771		Hour 6	0.787	0.675 to 0.875
	Hour 12	0.602	0.451 to 0.741		Hour 12	0.831	0.695 to 0.923
	Hour 24	0.544	0.391 to 0.692		Hour 24	0.772	0.625 to 0.882
uNGAL	Hour 3	0.711	0.621 to 0.790	Normalized uNGAL	Hour 3	0.707	0.617 to 0.787
	Hour 6	0.754	0.667 to 0.828		Hour 6	0.691	0.600 to 0.772
	Hour 12	0.660	0.517 to 0.785		Hour 12	0.745	0.607 to 0.855
	Hour 24	0.640	0.493 to 0.769		Hour 24	0.691	0.546 to 0.813
uα-GST	Hour 3	0.504	0.419 to 0.589	Normalized uα-GST	Hour 3	0.556	0.470 to 0.639
	Hour 6	0.523	0.437 to 0.608		Hour 6	0.54	0.454 to 0.624
	Hour 12	0.573	0.487 to 0.656		Hour 12	0.61	0.524 to 0.691
	Hour 24	0.633	0.547 to 0.713		Hour 24	0.542	0.456 to 0.627
uπ-GST	Hour 3	0.669	0.584 to 0.745	Normalized uπ-GST	Hour 3	0.547	0.462 to 0.631
	Hour 6	0.779	0.702 to 0.845		Hour 6	0.591	0.505 to 0.673
	Hour 12	0.586	0.500 to 0.668		Hour 12	0.594	0.508 to 0.676
	Hour 24	0.631	0.545 to 0.710		Hour 24	0.548	0.462 to 0.632

AUC area under the receiver-operating characteristic curve, CI confidence interval, uHJV urinary hemojuvelin, uKIM-1 urinary kidney injury molecule-1, uNGAL urinary neutrophil gelatinase-associated lipocalin, uα-GST urinary α-glutathione S-transferases, uπ-GST urinary π-glutathione S-transferases