Table 3.

Logistic regression analysis with variables available for predicting advanced acute kidney injury and model accuracy after combining urinary biomarkers

Model	AUC (95% CI)	p b
Hour 3
Normalized uHJV	0.833 (0.753 to 0.895)	NA
Normalized (uHJV + uKIM-1) a,c	0.898 (0.804 to 0.957)	0.468
Normalized (uHJV + uNGAL)	0.831 (0.751 to 0.893)	0.274
Normalized (uKIM-1 + uNGAL)	0.862 (0.760 to 0.932)	0.943
Normalized (uHJV + uKIM-1 + uNGAL)	0.897 (0.803 to 0.956)	0.496
Hour 6
Normalized uHJV	0.808 (0.726 to 0.874)	NA
Normalized (uHJV + uKIM-1)	0.827 (0.719 to 0.906)	0.785
Normalized (uHJV + uNGAL)	0.808 (0.726 to 0.874)	1.00
Normalized (uKIM-1 + uNGAL)	0.816 (0.707 to 0.898)	0.712
Normalized (uHJV + uKIM-1 + uNGAL)	0.834 (0.728 to 0.912)	0.634
Hour 12
Normalized uHJV	0.841 (0.715 to 0.927)	NA
Normalized (uHJV + uKIM-1)	0.890 (0.766 to 0.962)	0.332
Normalized (uHJV + uNGAL)	0.850 (0.725 to 0.933)	0.706
Normalized (uKIM-1 + uNGAL)	0.866 (0.736 to 0.947)	0.819
Normalized (uHJV + uKIM-1 + uNGAL)	0.892 (0.769 to 0.963)	0.311
Hour 24
Normalized uKIM-1	0.772 (0.625 to 0.882)	NA
Normalized (uKIM-1 + uHJV)	0.848 (0.711 to 0.936)	0.137
Normalized (uKIM-1 + uNGAL)	0.826 (0.686 to 0.921)	0.230
Normalized (uHJV + uNGAL)	0.730 (0.587 to 0.844)	0.567
Normalized (uKIM-1 + uHJV + uNGAL)	0.855 (0.720 to 0.941)	0.085

AUC area under the receiver-operating characteristic curve, CI confidence interval, NA not applicable, uHJV urinary hemojuvelin, uKIM-1 urinary kidney injury molecule-1, uNGAL urinary neutrophil gelatinase-associated lipocalin

^aHosmer-Lemeshow goodness of fit test: p = 0.541 for the best prediction model

^bCompared with normalized uHJV at hour 3, hour 6 and hour 12 and normalized uKIM-1 at hour 24

^cBest prediction model (greatest AUC)