Table 4.
Logistic regression analysis with variables available for predicting advanced acute kidney injury and model accuracy after combining clinical models with urinary biomarkers
| Model | AUC (95% CI) | p b |
|---|---|---|
| Liano’s score | 0.619 (0.536 to 0.698) | |
| Cleveland score | 0.493 (0.410 to 0.576) | |
| SOFA score | 0.700 (0.619 to 0.773) | |
| Hour 3 | ||
| Normalized uHJV | 0.833 (0.753 to 0.895) | NA |
| Liano’s + normalized uHJV | 0.817 (0.736 to 0.882) | 0.672 |
| Cleveland + normalized uHJV | 0.808 (0.726 to 0.874) | 0.662 |
| SOFA + normalized uHJV | 0.786 (0.701 to 0.856) | 0.419 |
| Normalized (uHJV + uKIM-1) | 0.898 (0.804 to 0.957) | 0.468 |
| Liano’s + normalized (uHJV + uKIM-1)a,c | 0.931 (0.846 to 0.977) | 0.206 |
| Cleveland + normalized (uHJV + uKIM-1) | 0.883 (0.785 to 0.946) | 0.817 |
| SOFA + normalized (uHJV + uKIM-1) | 0.876 (0.776 to 0.942) | 0.811 |
| Hour 6 | ||
| Normalized uHJV | 0.808 (0.726 to 0.874) | NA |
| Liano’s + normalized uHJV | 0.791 (0.707 to 0.860) | 0.653 |
| Cleveland + normalized uHJV | 0.769 (0.683 to 0.841) | 0.544 |
| SOFA + normalized uHJV | 0.759 (0.672 to 0.833) | 0.426 |
| Normalized (uHJV + uKIM-1 + uNGAL) | 0.834 (0.728 to 0.912) | 0.634 |
| Liano’s + normalized (uHJV + uKIM-1 + uNGAL) | 0.867 (0.766 to 0.935) | 0.334 |
| Cleveland + normalized (uHJV + uKIM-1 + uNGAL) | 0.817 (0.709 to 0.899) | 0.985 |
| SOFA + normalized (uHJV + uKIM-1 + uNGAL) | 0.812 (0.702 to 0.895) | 0.920 |
| Hour 12 | ||
| Normalized uHJV | 0.841 (0.715 to 0.927) | NA |
| Liano’s + normalized uHJV | 0.834 (0.707 to 0.922) | 0.879 |
| Cleveland + normalized uHJV | 0.892 (0.776 to 0.960) | 0.429 |
| SOFA + normalized uHJV | 0.834 (0.705 to 0.923) | 0.656 |
| Normalized (uHJV + uKIM-1 + uNGAL) | 0.892 (0.769 to 0.963) | 0.311 |
| Liano’s + normalized (uHJV + uKIM-1 + uNGAL) | 0.923 (0.808 to 0.980) | 0.151 |
| Cleveland + normalized (uHJV + uKIM-1 + uNGAL) | 0.916 (0.800 to 0.976) | 0.281 |
| SOFA + normalized (uHJV + uKIM-1 + uNGAL) | 0.914 (0.795 to 0.975) | 0.302 |
| Hour 24 | ||
| Normalized uKIM-1 | 0.772 (0.625 to 0.882) | NA |
| Liano’s + normalized uKIM-1 | 0.799 (0.655 to 0.902) | 0.488 |
| Cleveland + normalized uKIM-1 | 0.765 (0.617 to 0.877) | 0.737 |
| SOFA + normalized uKIM-1 | 0.797 (0.650 to 0.902) | 0.587 |
| Normalized (uKIM-1 + uHJV + uNGAL) | 0.855 (0.720 to 0.941) | 0.085 |
| Liano’s + normalized (uKIM-1 + uHJV + uNGAL) | 0.882 (0.753 to 0.958) | 0.030 |
| Cleveland + normalized (uKIM-1 + uHJV + uNGAL) | 0.863 (0.729 to 0.946) | 0.096 |
| SOFA + normalized (uKIM-1 + uHJV + uNGAL) | 0.869 (0.735 to 0.951) | 0.082 |
AUC area under the receiver-operating characteristic curve, CI confidence interval, SOFA score Sequential Organ Failure Assessment score, uHJV urinary hemojuvelin, uKIM-1 urinary kidney injury molecule-1, uNGAL urinary neutrophil gelatinase-associated lipocalin
aHosmer-Lemeshow goodness of fit test: p = 0.481 for the best prediction model
bCompared with normalized uHJV at hour 3, hour 6 and hour 12 and normalized uKIM-1 at hour 24
cBest prediction model (greatest AUC), combined clinical model (Liano’s score) with biomarkers