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. 2018 Apr 27;18:478. doi: 10.1186/s12885-018-4373-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Genes in cholesterol synthesis pathway are coherently downregulated in prostate cancer compared to normal epithelium. a The figure shows –log10 p-values multiplied by 1 for upregulated genes, and − 1 for downregulated genes. The results presented are for a rank-based meta-analysis of the five-study-cohort. All p-values presented are corrected for multiple testing using the total number of 25,964 unique gene identifiers from all cohorts. Results from individual cohorts as well as the seven-study-cohort can be found in Additional file 1: Figure S4. b The schematic representation shows the cholesterol synthesis pathway with down- and upregulated genes color-coded in blue and red, respectively. The strength of the color corresponds to the degree of down- or upregulation