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. Author manuscript; available in PMC: 2018 Apr 27.
Published in final edited form as: Cancer Res. 2017 Jun 26;77(16):4460–4471. doi: 10.1158/0008-5472.CAN-17-0015

Figure 2. Low nutrient conditions promote chemotherapy resistance in PDAC (in vivo mouse and in patients).

Figure 2

A, Tumor growth curves of MiaPaCa2 PDAC xenografts in mice fed an HC or a ketogenic and calorie restricted diet (75% of the average caloric intake, KCR75). Each data point represents the mean ± SEM (n= 5 per group). *, P < 0.05; **, P < 0.01; ***, P < 0.001. B, Cox multivariate disease-free survival in patients receiving gemcitabine after resection for PDAC. See also Supplementary Fig. S2. GEM, gemcitabine.