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. Author manuscript; available in PMC: 2018 Apr 27.
Published in final edited form as: Cancer Res. 2017 Jun 26;77(16):4460–4471. doi: 10.1158/0008-5472.CAN-17-0015

Figure 3. HuR protects PDAC cells against nutrient withdrawal and chemotherapy.

Figure 3

A, Tumor growth curves of MiaPaCa2 PDAC xenografts containing a doxycycline (DOX)-inducible shRNA construct against HuR (MiaPaCa2.sh.HuR). Mice were fed an HC diet, a ketogenic diet with 75% caloric intake (KCR75), or a ketogenic diet with 50% caloric intake (KCR50). Each data point represents the mean ± SEM (n= 8 per group). B, PicoGreen cell survival and drug sensitivity assays in MiaPaCa2 cells treated with gemcitabine (GEM). See also Supplementary Figs. S3 and S4.