Figure 1. Effects of allelic reduction of the Ctnnb1 gene.

(A and B) Allelic reduction of the Ctnnb1 gene reduced the active, nuclear, and total β-catenin levels. (B) Representative Western blots of tissue lysates from the kidneys of Pkd2^f/f, Vil^CrePkd2^f/f, and Vil^CrePkd2^f/fCtnnb1^+/– mice are shown, along with (B) normalized quantitative analysis of the densitometry values of the tested tissues. (C and D) Allelic reduction of the Ctnnb1 gene suppressed β-catenin–mediated transcription (including Axin2, c-Myc, and cyclin D1) activated by PC2 deficiency. All data are presented as mean ± SEM (*P < 0.05, **P < 0.01, Student’s t test). Data are from 3 animals/group.