Figure 3. XAV939 impedes cyst formation in Vil^CrePkd2^f/f mice.

(A) Diagram showing the XAV939 injection schedule. (B) Representative kidney images and histology. Scale bars: 3 mm (top); 600 μm (bottom). (C–F) Renal cystic index, kidney/body weight ratio, and the renal function parameters, blood urea nitrogen (BUN) and creatinine (Cr). Circled dots represent the mice from which representative kidney images and histology (B) were taken. (G and H) XAV939 did not affect apoptosis but (I and J) did reduce proliferation (n = 3). (K) XAV939 significantly prolonged the survival of Vil^CrePkd2^f/f mice (P < 0.05). Data in C–J are presented as mean ± SD (*P < 0.05; **P < 0.01, ***P < 0.001, ANOVA).