Skip to main content
. 2018 Mar 8;3(5):e95874. doi: 10.1172/jci.insight.95874

Figure 4. LGK974 treatment delayed cyst formation in VilCrePkd2f/f mice.

Figure 4

(A) Diagram showing the LGK974 treatment schedule. (B) Representative kidney images and histology. Scale bars: 3 mm (top); 600 μm (bottom). (C–F) Renal cystic index, kidney/body weight ratio, and the renal function parameters, blood urea nitrogen (BUN) and creatinine (Cr). Circled dots represent the mice from which representative kidney images and histology (B) were taken. (G and H) LGK974 did not affect apoptosis but (I and J) did reduce proliferation (n = 3). (K) LGK974 prolonged the survival of VilCrePkd2f/f mice (P < 0.05). Data in C–J are presented as mean ± SD (*P < 0.05; **P < 0.01, ***P < 0.001, ANOVA).