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. 2018 Mar 8;3(5):e95874. doi: 10.1172/jci.insight.95874

Figure 6. The effect of Wnt inhibitors XAV939 and LGK974 on the PC2/Wnt/β-catenin molecular pathway.

Figure 6

The loss of PC2 elevates Wnt7a and Wnt9a expression, leading to β-catenin activation and β-catenin–mediated transcription activation. This eventually increases renal epithelial cell proliferation and promotes cystogenesis. Treatment with XAV939 or LGK974 suppresses β-catenin activity and decreases the expression of downstream Wnt signaling factors, such as Axin2, c-Myc, and cyclin D1, thereby arresting aberrant cell proliferation and inhibiting cystogenesis.