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. 2018 Mar 8;3(5):e96151. doi: 10.1172/jci.insight.96151

Figure 6. Human LRH-1 complements mouse LRH-1 and prevents hepatocyte TG accumulation.

Figure 6

(A) Expression of mouse LRH-1 or flag-tagged human LRH-1 in liver 8 weeks after infection with AAV8-Cre (CRE), AAV8-GFP (GFP), or AAV8-CRE+Fl-hLRH-1 (CRE+hLRH-1). (B) Relative expression of known or new LRH-1 gene targets and expression of lipid droplet–associated genes in livers in 3 groups: Lrh-1AAV8-GFP, Lrh-1AAV8-Cre, and Lrh-1AAV8-Cre+hLrh1. The number per group for all measurements is n = 5, 6, and 4. (C) TG levels in hepatocytes isolated 2 weeks after infection from at least 2 mice, performed in triplicate. Error bars represent ± SEM. For box-and-whisker plots, maximum and minimum values are shown with median. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, unpaired Student’s t test for B and C.