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. 2018 Apr 23;13:2491–2505. doi: 10.2147/IJN.S157935

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© 2018 Lu et al. This work is published and licensed by Dove Medical Press Limited

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Efficacy of various therapeutic strategies in treating nude mice bearing U251 glioma tumors.

Notes: (A) The quality and volume changes of stripped tumors in various treatment groups. (B) Tumors rejected from mice in various treatment groups. (C) Histopathologic examination of human glioma transplanted in nude mice (hematoxylin/eosin staining, ×100 magnification). Transmission electron microscopy of the tumors exposed to Fe₃O₄@Au-C225 MNPs-mediated combined hyperthermia (MFH+NIR). (D) Numerous vesicles containing the aggregative Fe₃O₄@Au-C225 MNPs. (E) The denatured collagen zones in the close vicinity of Fe₃O₄@Au-C225 MNPs localization. *Compared with the negative control group, P<0.05; ^#Fe₃O₄@Au-C225 MNPs compared with Fe₃O₄@Au MNPs when exposed to AMF combined with NIR, P<0.05.

Abbreviations: AMF, alternating magnetic field; C225, cetuximab; MFH, magnetic fluid hyperthermia; MNPs, magnetic nanoparticles; NIR, near-infrared hyperthermia.