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. 2018 Apr 10;9(27):18665–18681. doi: 10.18632/oncotarget.24816

Table 1. Fold changes in mRNA levels of endosomal and cytosolic DNA sensors in TS/A tumor cells 4 hours after pDNA electrotransfer.

TS/A control gWiz Blank EP1 EP2 EP3 pDNA+EP1 pDNA+EP2 pDNA+EP3
n foldex ± SE n foldex ± SE n foldex ± SE n foldex ± SE n foldex ± SE n foldex ± SE n foldex ± SE n foldex ± SE
TLR9 8 / 6 / 3 / 2 / 3 / 4 / 3 / 3 /
RIG-1 8 / 6 / 3 / 2 / 3 / 4 / 3 / 3 /
DDX60 9 1.2 ± 0.3 6 0.7 ± 0.3 4 0.7 ± 0.2 2 1.7 ± 1.2 3 0.8 ± 0.0 7 3.2 ± 0.7* 5 4.0 ± 0.9* 3 1.0 ± 0.2
DHX9 8 1.2 ± 0.2 6 0.3 ± 0.1 4 0.4 ± 0.1 2 1.7 ± 1.2 3 1.3 ± 0.2 4 0.1 ± 0.0 3 1.4 ± 0.3 3 0.8 ± 0.1
DHX36 9 1.3± 0.4 6 0.6± 0.1 4 0.9 ± 0.3 2 1.7 ± 1.2 3 0.9 ± 0.1 4 7.7 ± 1.2* 5 1.9 ± 1.0 3 0.6 ± 0.1
AIM 8 / 5 / 3 / 2 / 3 / 3 / 3 / 3 /
cGAS 7 1.4 ± 0.5 5 1.1 ± 0.3 3 1.0 ± 0.4 2 1.9 ± 1.1 3 1.7 ± 0.1 3 1.6 ± 0.6 3 1.0 ± 0.1 3 1.1 ± 0.1
DAI/ZBP1 8 1.7 ± 0.5 4 1.5 ± 1.2 3 0.7 ± 0.1 2 1.7 ± 1.2 3 1.1 ± 0.2 5 14.1 ± 3.9* 3 3.0 ± 0.6* 3 1.0 ±0.1
DDX41 6 1.1 ± 0.2 4 1.3 ± 0.2 3 1.6 ± 0.4 2 1.8 ± 1.1 3 1.2 ± 0.2 3 1.3 ± 0.5 3 1.3 ± 0.2 3 0.9 ± 0.0
LRRFIP1 6 0.8 ± 0.1 5 0.8 ± 0.1 3 1.1 ± 0.2 2 1.8 ± 1.1 3 1.2 ± 0.1 3 2.2 ± 0.8 3 2.8 ± 1.2 3 0.9 ± 0.0
P202 7 1.2 ± 0.2 5 0.8 ± 0.3 3 0.7 ± 0.3 2 1.7 ± 1.2 3 0.9 ± 0.0 3 2.8 ± 1.0 3 4.1 ± 2.4 3 1.0 ± 0.1
P204 3 1.0 ± 0.2 2 1.0 ± 0.1 2 0.6 ± 0.1 2 1.9 ± 0.5 3 1.2 ± 0.1 3 1.1 ± 0.1 3 3.4 ± 0.3* 3 2.1 ± 0.2*
SOX2 4 / 2 / / 2 / 2 / 3 / 3 / 2 /
MRE1 4 1.2 ± 0.2 2 1.5 ± 0.4 2 0.8 ± 0.1 2 1.0 ± 0.1 2 0.6 ± 0.0 3 0.8 ± 0.2 3 0.9 ± 0.1 2 0.5 ± 0.0
Ku70 4 0.9 ± 0.2 2 1.0 ± 0.1 2 1.1 ± 0.0 2 0.8 ± 0.1 2 1.0 ± 0.0 3 1.0 ± 0.1 3 0.8 ± 0.1 2 1.0 ± 0.0

Legend: cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase; DAI/ZBP1, DNA-dependent activator of interferon regulatory factor; DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; DDX60, DEAD (Asp-Glu-Ala-Asp) box polypeptide 60; DHX9, DEAH (Asp-Glu-Ala-His)box helicase 9; DHX36, DEAH (Asp-Glu-Ala-His) box helicase 36; LRRFIP1, leucine-rich repeat flightless-interacting protein 1; p204, interferon activated gene 204; p202, interferon activated gene 202; MRE11, meiotic recombination 11 homolog, double strand break repair nuclease; SOX2, SRY (sex determining region Y)-box 2; Ku70, Lupus Ku autoantigen protein p70*statistically significant difference compared to control group (P < 0.05); ND, not detected.