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. 2018 Apr 10;9(27):18821–18831. doi: 10.18632/oncotarget.24568

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Copyright: © 2018 Goto et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) The in vitro ADAM10 enzyme assay system was validated using the known inhibitor MMS as a positive control. (B) The effects of 636 compounds in the FDA-Approved Drug Screen-well Library were tested in vitro. (C) The chemical structures of DSF and its analogues and metabolites, retrieved from the database ChemSpider. In vitro effects of (D) DSF, TR and TMTM at 0.5, 1, and 10 μM, and (E) DDC, DETC-MeSO and DDTC-MeSO at 1 and 10 μM.