Figure 3. A Pcna^K164R mutation renders lymphomas highly sensitive to CsPt treatment.

(A) Representative examples of DDT^P or DDT^D tumor bearing mice at the beginning (right), and at the end of the CsPt treatment (left). (B) Kaplan – Meier curve of mice carrying DDT^P or DDT^D tumors. ^**p = 0.0011 by Mantel-Cox test when comparing DDT^P or DDT^D tumor bearing mice treated with CsPt. Treated groups received 6 mg/kg CsPt every two weeks, starting from the first bioluminescent signal detection by IVIS.