Figure 4. Low dose CsPt therapy is effective in DDT-defective lymphomas.

(A) Curve represents the flux of bioluminescence signal from IVIS detection of mice (n = 5) carrying WT tumor in response to 2 mg/kg CsPt treatment every two weeks. Each line represents an indicated mouse. (B–C) As in A but DDT^D lymphoma (n = 8) readouts are displayed. (D) Representative examples of DDT^P or DDT^D lymphoma bearing mice at the beginning of the 2 mg/kg CsPt treatment, maintained every two weeks. (E) As in (D) but at the end of the CsPt regime. (F) Kaplan–Meier curve of mice carrying tumor with indicated genotypes upon 2 mg/kg CsPt treatment. ^***p = 0.0001 by Mantel Cox test.