Table 3. NUMB protein expression intensity and cellular localization in samples of patients (n = 144) with CIN and ICC treated at the Instituto Nacional de Cancerologia-México from 2004 to 2017.
| CIN (n = 49) | ICC (n = 49) | P-value | |||
|---|---|---|---|---|---|
| n | (%) | n | (%) | ||
| Intensitya | |||||
| Negative | 32 | (65.31%) | 40 | (42.11%) | |
| Weak | 17 | (34.69%) | 49 | (51.58%) | 0.014 |
| Intense | 0 | (0.00%) | 6 | (6.31%) | |
| Localization | |||||
| Negative | 32 | (65.31%) | 40 | (42.11%) | |
| Membrane | 0 | (0.00%) | 2 | (2.10%) | |
| Cytoplasm | 1 | (2.04%) | 34 | (35.79%) | |
| Nucleus | 16 | (32.65%) | 6 | (6.32%) | ˂0.001 |
| Mem/cytob | 0 | (0.00%) | 8 | (8.42%) | |
| Cyto/nucc | 0 | (0.00%) | 5 | (5.26%) | |
CIN: Cervical intraepithelial neoplasia. ICC: Invasive cervical cancer. aIntensity was categorized as weak = + and ++; and intense = +++ by immunohistochemistry. bPresence of the protein at the membrane and in the cytoplasm. cPresence of the protein in the cytoplasm and nucleus. Bold: statistically significant.