Table 3. HMGB1 Y2H preys in a library from ovarian tissue.

Gene	N	Function	Relation to cancer
C3	1	Cell Proliferation	Secretion of Complement C3 protein in ovarian cancer cells promotes cell proliferation, invasion, and migration [51].
CCAR1	3	Apoptosis	Cell division cycle and apoptosis regulator 1 regulates cell growth and apoptosis by serving as a co-activator of several genes including steroid nuclear receptors and tumor suppressor p53 [48].
KRT7	5	Cytoskeleton	KRT7 7, KRT18 and KRT19 are differentially expressed in circulating tumor cells in ovarian cancer patients [49].
MT2A	1	Apoptosis	MT2A is upregulated in chemotherapy resistant ovarian tumors, and also in human prostate cell lines [50].
RPS12	1	Cell Proliferation	RPS12 encodes the 40S ribosomal protein S12. RPS12 expression changes in breast cancer [101].

N: repetitive identification during Y2H screening.