Table 3.
Logistic regression analysis: relationship between index exacerbation severity and subsequent exacerbation, hospitalization, or death within 60 days following first on-treatment exacerbation
| Subsequent event | Index on-treatment exacerbation
|
|||
|---|---|---|---|---|
| Moderate
|
Severe (requiring hospitalization) | |||
| Treated with antibiotics only | Treated with systemic corticosteroids only | Treated with antibiotics and systemic corticosteroids | ||
| No of patients in the exacerbation analysis | N=3,028 | N=791 | N=2,577 | N=1,359 |
| Moderate to severe exacerbation, n (%) | 369 (12.2) | 116 (14.7) | 420 (16.3) | 158 (11.6) |
| OR (95% CI) | – | 1.26 (1.00–1.57) | 1.37 (1.18–1.59) | 0.90 (0.74–1.10) |
| Severe exacerbation, n (%) | 49 (1.6) | 22 (2.8) | 71 (2.8) | 106 (7.8) |
| OR (95% CI) | – | 1.75 (1.03–2.87) | 1.67 (1.16–2.42) | 4.91 (3.49–6.99) |
| No of patients in the hospitalization, death, and discontinuation analysis | N=3,070 | N=820 | N=2,660 | N=1,486 |
| Hospitalization (all-cause), n (%) | 107 (3.5) | 40 (4.9) | 135 (5.1) | 283 (19.0) |
| OR (95% CI) | – | 1.41 (0.96–2.03) | 1.46 (1.13–1.89) | 6.44 (5.12–8.15) |
| Death (all-cause), n (%) | 10 (0.3) | 7 (0.9) | 21 (0.8) | 61 (4.1) |
| OR (95% CI) | – | 2.72 (0.98–7.10) | 2.47 (1.19–5.49) | 12.97 (6.93–27.02) |
| Discontinuation, n (%) | 66 (2.2) | 40 (4.9) | 102 (3.8) | 169 (11.4) |
| OR (95% CI) | – | 2.33 (1.55–3.46) | 1.82 (1.33–2.50) | 5.85 (4.39–7.88) |
Notes: Percentages shown are “column” percentages. OR was calculated for subsequent events within 60 days started either after the onset of the first exacerbation (not leading to discontinuation) (for subsequent hospitalization, death, and discontinuation) or after the end of the first exacerbation (not leading to discontinuation) (for subsequent exacerbation). OR was calculated for patients treated with antibiotics only and adjusted for inhaled corticosteroid use at baseline and exacerbation in the year prior to study.
Abbreviation: OR, odds ratio.