. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Int J Cancer. 2018 Feb 8;142(11):2215–2226. doi: 10.1002/ijc.31249

Table 4. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for breast cancer associated with AMH concentration.

	AMH quartiles¹				P_trend⁵
					P_trend⁵
	Q1	Q2	Q3	Q4
Cases/Controls	631/789	684/777	711/779	809/777	.
Unadjusted OR² (95% CI)	1.00 (Referent)	1.20 (1.02, 1.41)	1.35 (1.14, 1.61)	1.64 (1.35, 1.98)	<.0001
Adjusted OR³ (95% CI)	1.00 (Referent)	1.18 (1.00, 1.39)	1.32 (1.10, 1.58)	1.60 (1.31, 1.94)	<.0001
Adjusted OR³ (95% CI), among women with testosterone measurements	1.00 (Referent)	1.18 (0.99, 1.40)	1.34 (1.11, 1.61)	1.62 (1.32, 1.98)	<.0001
Adjusted OR⁴ (95% CI), including adjustment for testosterone	1.00 (Referent)	1.17 (0.99, 1.40)	1.33 (1.10, 1.60)	1.58 (1.29, 1.93)	<.0001

Defined using cohort-specific cutpoints.

Estimated using conditional logistic regression (cohort and age are adjusted for through matching).

Estimated using conditional logistic regression and adjusting for race/ethnicity (white, black, other or unknown), education (high school or less, some college or higher, unknown), BMI (ordered categorical, <18.5, 18.5-25, 25-30, 30+ kg/m²), age at menarche (ordered categorical, <12, 12, 13, 14+ years), parity (ordered categorical, 0, 1, 2, 3+), age at 1^st FTP (ordered categorical, <=20, 21-25, 26-30, 30+ years or nulliparous), oral contraceptive use (never, former, current, unknown), partial oophorectomy (no, yes, unknown), family history of breast cancer (no, yes), benign breast biopsy (no, yes, unknown), and smoking status (never, former, current, unknown).

⁴

Estimated using conditional logistic regression and adjusting for variables in footnote 2 and testosterone (cohort-specific quartiles, with measurements from previous studies calibrated to the Mayo LC-MS/MS assay).

⁵

P_trend was calculated using ordered-categorical AMH.