Fig. 8.

(A–C) Dose-dependent effects on cardiovascular parameters 10 min after epinephrine with and without phentolamine. Key differences are recorded at the highest dose of epinephrine. Phentolamine pretreatment (P) is protective in all parameters. Mean values are plotted with error bars indicating SEM; # indicates difference following epinephrine alone from baseline value; + indicates difference in the phentolamine pretreatment group from their baseline value; * indicates difference between the two groups. Symbol number indicates significance: one symbol, P less than 0.05; two symbols, P less than 0.01; three symbols, P less than 0.001, four symbols, P less than 0.0001.